SIX2 and fibrosis: While the promoter of the Nsf (nephrogenic system fibrosis) gene was co-occupied by Eya1/Six2, Six2 alone also bound to a distal intronic CRE/enhancer ∼+70-kb, and Eya1 alone occupied another distal intronic CRE ∼+35-kb without H3k27ac-deposition but with two REST motifs (Figure 4E).