This module included a number of immediate early and growth factor response genes and overlapped with modules previously identified for SDF1 responses in PBs (genes such as CD69 and NR4A2) and growth factor responses in cancer (genes such as EGR1/3, FOS, FOSB, and IER2) (Supplemental Fig. 4) (6, 24). This evidence concerns the gene IER2 and cancer.