The expression gene analysis showed that PTGFR (downregulated) and GPR56 (upregulated) are differentially expressed in placentas of women with sickle cell anemia as well as SPOCK1 (downregulated) and ADCY4 (upregulated) in placentas of women with hemoglobinopathy HbSC. This evidence concerns the gene SPOCK1 and sickle cell disease.