HLA-DRB1 and neoplasm: Furthermore, ESTIMATE algorithms and CIBERSORT computational method were applied to estimate the ratio of tumor-infiltrating immune cell (TIC) and the proportion of immune cell and stromal cell and identified a predictive factor, HLA-DRB1(major histocompatibility complex, class II, DR beta 1), which may be a latent indicator for reflecting the change of TME status in CM was identified.