RSPO3-correlated cancer genes involved in more than four pathways were as follows; JUN was involved the most in 9 of 10 pathways, APC, 6 pathways, AXIN2, 5 pathways, FGFR2, 5 pathways, JAK2, 7 pathways, MDM2, 5 pathways, MYC, 9 pathways, RAC1, 8 pathways, and lastly, TP53, 7 pathways. This evidence concerns the gene TP53 and cancer.