GSEA also revealed the negative enrichment of gene sets associated with unfolded protein response (UPR), apoptosis, IRF4 target genes, CD40 signaling, MHC class II (MHC-II), and MYC targets in POEMS clones compared with those in controls, POEMS nonclones, MGUS clones, and/or MM clones (Figure 3, B and C). Here, MYC is linked to Miyoshi myopathy.