A significant degree of ACTH-dependent hypercortisolemia was diagnosed [UFC: 7155 μg/24 h (N: 4.3–176) midnight serum cortisol: 69.64 μg/dL (N: < 5.4), ACTH: 167 pg/mL (N: 6–48)]. The gene discussed is POMC; the disease is adrenal gland hyperfunction.