IFNA1 and COVID-19: The delayed and diminished IFN response in severe COVID-19 is associated with a late and dysregulated inflammatory gene expression signature (Park and Iwasaki, 2020; Wong and Perlman, 2022; Galani et al., 2021; Hadjadj et al., 2020), possibly due to enhanced tissue damage caused by an insufficient control of virus replication.