In a panel of soft-tissue sarcoma cell lines induced into senescence by irradiation, BCL-2 or BCL-xL were differentially increased depending on the cell line, but the cells were all comparably sensitive to senolysis by venetoclax or navitoclax, irrespectively of BCL-2 and BCL-xL expression levels [68]. The gene discussed is BCL2L1; the disease is soft tissue sarcoma.