On the contrary, if ANGII binds directly to AT2 receptor or converts to ANGIII and then binds to AT2 receptor or converts to ANG (1–7) and then adjoins to ANG (1–7) receptor (MasR), atherosclerosis, hypertrophy, fibrosis, proliferation and vasoconstriction are diminished and natriuresis and diuresis are elevated [38]. The gene discussed is ANGPT1; the disease is atherosclerosis.