RSPO4 and cancer: In addition to proteins related to ATP production, proteins whose interactions with other proteins affect the growth of cancer cells are downregulated, including CEACAMP7 and RSPO4 that play a role in cancer cells; ZBTB8B that involved in cancer cell development; NXPH3 interacts with proteins associated with microtubule formation and metastasis; SOAT2 and FBXW12 proteins that interact with the cancer cell cycle and growth-related proteins (Figure 4B).