SDHB and renal cell carcinoma: Germline mutations in the SDH genes (A, B, C, D, or AF2) cause a Hereditary Paraganglioma and Pheochromocytoma (HPGL/PCC) syndrome, with a predisposition towards paragangliomas, pheochromocytomas, gastrointestinal stromal tumors, and renal cell carcinomas (RCC) [6].