If, by one hand, hypoxia is a common feature for solid tumors, contributing locally and systemically to tumor progression, lack of response to radiotherapy and chemotherapy, increasing the probability of tumor recurrence [20], on the other hand, the transcription factor HIF-1 that is the major regulator of tumor adaptation to hypoxia, may induce the expression of an array of genes with distinct functions [21]. This evidence concerns the gene HIF1A and neoplasm.