A signature score based on biomarkers expression levels with regression estimates as weights (Biomarker Score = 1.03 × cytoplasmic β-catenin + 0.73 × nuclear c-Myc + nuclear 1.07 × DVL – 1.22 × α-catenin membrane) was strongly associated with prognosis of ESCC recurrence/death [HR = 1.11 (95% CI = 1.05, 1.17), p < 0.001, c-statistic = 0.68, Table 3]. This evidence concerns the gene MYC and esophageal squamous cell carcinoma.