Similar increase in cytoplasmic levels of E-cadherin, α-catenin, c-Myc, and DVL was observed in esophageal dysplasia and ESCC as compared to the normal esophageal tissues, while nuclear expression of c-Myc and DVL was also observed in these tissues as shown in panels B (i–iii) to E (i–iii) respectively. This evidence concerns the gene DVL1 and esophageal squamous cell carcinoma.