Esophageal dysplasia showed significant loss of membrane and accumulation in cytoplasmic E-cadherin, β-catenin and α-catenin in comparison with the normal esophageal tissues that is sustained in ESCC revealing the potential of these proteins as biomarkers for distinguishing dysplasia from normal esophageal tissues. The gene discussed is CDH1; the disease is esophageal squamous cell carcinoma.