Slug has recently been demonstrated to be a target gene in the signalling cascade TGF-β-PI3K/Akt-GSK3β-Snail-Slug-CD147, involved in epithelial mesenchymal transition and is implicated in hepatocarcinogenesis and hepatocellular carcinoma metastasis [24]. This evidence concerns the gene AKT1 and hepatocellular carcinoma.