Recently Song et al., [1, 2] based on a comprehensive genomic analysis of 158 ESCC cases reported that ESCC and HNSCC pathogenesis may share many common characteristics including activation of MAPK, JAK-STAT, Wnt, NOTCH pathways and CNA profiles of many genes in cell cycle. This evidence concerns the gene SOAT1 and esophageal squamous cell carcinoma.