The inflammatory basis of the COVID-19 that includes cytokine storm syndrome because of excessive synthesis of IL-6 and also due to the anti-inflammatory effects of colchicine on the innate immune system by stabilizing of PMNs15,16; it seems colchicine could be effective in improving systemic COVID-19 symptoms such as fever, which is undoubtedly induced by inflammatory biomarkers, eg, IL-6 and TNF (tumour-necrosis factor). Here, TNF is linked to COVID-19.