IL6 and infection: Many studies have suggested that an over-reaction of the immune system by virus can cause the complicated features of disease.5 Cytokine storm syndrome is the severe immune reaction that may cause a severe tissue response in these patients.6 By innate immune system stimulation, NLRP3, an inflammasome compartment activates IL-18, IL-1β, and IL-6.7 Excessive synthesis of IL-6 against infection leads to an acute systemic inflammatory reaction known as cytokine storm.8