PGF and preeclampsia: There are some studies that have established sFlt-1 as proangiogenic and antiangiogenic factors.15 In previous years, sFlt-1 was widely used as a predictor in cases of placenta-related disorders such as preeclampsia.20 This is because in preeclampsia, implantation that occurs is usually superficial due to failure of the transformation of the spiral arteries, therefore there is usually an increase in sFlt-1 levels and decrease in placental growth factor (PLGF) level.