It has also been observed that hypercalcemia happened more frequently in patients with plasma cell leukemia, a late stage complication of myeloma,56, 57 and in patients with Durie‐Salmon stage III disease, circulating monomeric human calcitonin levels and corrected serum calcium were significantly higher than stage I.58As for LDH, which has been shown as an important prognostic indicator of disease severity,59 might be affected by multiple factors such as hemolysis, and thus no significant difference was observed in our study. This evidence concerns the gene CALCA and hypercalcemia disease.