Mechanically, numbers of previous studies focused on the detection of PRDM5 gene methylation status,7, 8, 9, 17 which was determined contributing to the silencing of PRDM5 in several tumor tissues include lung cancer, few literatures elucidated the potential mechanisms of PRDM5 tumor suppressive functions in LUAD carcinogenesis. This evidence concerns the gene PRDM5 and lung cancer.