The inhibitory effects of β-escin on tumor growth were accompanied by a decrease in Ki-67 index (***p<0.001, Fig. 5I and Additional file 1: Fig. S2A) and a significant increase in apoptosis as determined by TUNEL-positivity representing DNA fragments (****p<0.0001, Fig. 5J and Additional file 1: Fig. S2B). This evidence concerns the gene MKI67 and neoplasm.