In multivariate logistic regression analysis after adjustment for other indicators, the serum concentration of ADAMTS13 at 72 h post-IVT functioned as a protective factor and was an independent predictor for functional outcome of AIS patients with an adjusted OR of 0.07 (95% CI, 0.005–0.991, P = 0.049), whereas IL-6 at 72 h post-IVT was an independent risk factor in functional outcome with an adjusted OR of 1.152 (95% CI,1.015–1.308, P = 0.028). The gene discussed is ADAMTS13; the disease is androgen insensitivity syndrome.