Zhang et al. demonstrated that miltirone inhibited HCC cells growth through BAX–caspase–GSDME-dependent pyroptotic by regulating ROS/mitogen-activated and extracellular signal-regulated kinase (MEK)/extracellular regulated protein kinases 1/2 (ERK1/2) pathway [36]. The gene discussed is MAP2K7; the disease is hepatocellular carcinoma.