We determined the translational relevance by first examining human wound Mφs analyzed previously by our group [10] using single-cell RNA sequencing (scRNA-seq) from T2D and non-T2D patients and found that JMJD3, along with IL-6, TNF-α, IL-1β, and IL23, was significantly increased in Mφs from chronic wounds of T2D patients (Fig. 2A, Supplementary Fig. 3). Here, TNF is linked to type 2 diabetes mellitus.