AKT2 and neoplasm: Importantly, inhibition of specific AKT isoforms has been shown to have differential effects on tumour vascularisation, invasion and metastasis: inhibition of AKT3 in triple negative breast cancer was shown to increase migration in vitro, and subsequent studies demonstrated combined inhibition of either AKT1/3 or AKT2/3 resulted in increased metastasis formation in vivo32.