Excluding the SAPS3 Box III caused no changes in the model on COVID-19 and ARDS, however, the impact of obesity became differential between the COVID-19 and Sepsis groups as the p-value for the interaction with the disease group affiliation variable changed from 0.07 to 0.03 (Supplementary Tables S10 and S11 online). This evidence concerns the gene PPP6R3 and obesity due to melanocortin 4 receptor deficiency.