Excluding the SAPS3 Box III caused no changes in the model on COVID-19 and ARDS, however, the impact of obesity became differential between the COVID-19 and Sepsis groups as the p-value for the interaction with the disease group affiliation variable changed from 0.07 to 0.03 (Supplementary Tables S10 and S11 online). This evidence concerns the gene PPP6R3 and obesity disorder.