PPARG and breast cancer: In an exploratory initial study, we assessed whether possible activation of PPAR-γ signaling, indirectly through administration of the biguanide metformin82,83 (one of the agents used as standard of care treatment of diabetes mellitus84,85): (i) might be involved in clinical outcome of BC patients, and (ii) might be related to LIPEC abundance, realizing that metformin may have additional mechanisms of action.