GAS6 and neoplasm: The analysis predicted known interactions that are presumably involved in polarizing macrophages towards an immunosuppressive phenotype by ECs, for instance between angiogenic ECs and TAMs (Mye1) (both enriched in the tumor setting, Supplementary Data 5) expressing respectively GAS6 (angiogenic ECs) ⇔ MERTK, AXL (Mye1, TAMs)47–49, suggested to promote immunosuppressive TAM infiltration50 (Fig. 4f).