HES1 is involved in vascular remodeling and specification of arterial fate in ECs94, but also reported as a repressor of PPAR-γ95,96, and the role of HES1 in LIPEC differentiation, molecular makeup (e.g., expression of FABP4 and other genes involved in lipid metabolism) and function in cancer thus warrants further attention. The gene discussed is FABP4; the disease is cancer.