Compared to vein pECs, vein TECs exhibited lower expression levels of a number of genes, involved in antigen presentation (HLA-DRB1, HLA-DRB5, and HLA-DRA)19,31, immune cell recruitment (SELP, LIFR, and ACKR1)32–34 and anti-tumor inflammation (CCL14, IFITM1)35,36 (Supplementary Fig. 3c). This evidence concerns the gene HLA-DRB5 and neoplasm.