ACE and COVID-19: Based on limited preclinical data, it was hypothesized that NSAIDs (particularly ibuprofen, which is available worldwide over the counter [OTC] and the most commonly used NSAID) may be detrimental to patients with COVID-19 due to upregulation of angiotensin-converting enzyme (ACE) 2 expression, which, in turn, may facilitate viral entry into host cells and enhance pathogenicity of the viral load14,18.