Based on results of both experiments, we found that after silencing of circFTO or overexpression of miR-514b-3p, the proliferation ability of ccRCC cells were tremendously suppressed, and the suppression could be reversed by inhibition of miR-514b-3p and overexpression of DUSP4 (Fig. 5A, E, F). Here, DUSP4 is linked to nonpapillary renal cell carcinoma.