We previously found that human pancreatic cancer AsPC-1 and MIA PaCa-2 cells with high EGFR/HER2 expression showed the strongest binding affinity to DTLP, the precursor of DTLL, however, the AsPC-1 cell line or xenograft tumor showed intermediate resistance to DTLL, whereas MIA PaCa-2 had stronger affinity and better response25. Here, EGFR is linked to familial pancreatic carcinoma.