Collectively, these results illustrated that hypoxia-responsive long noncoding NDRG1-OT1 could be transcriptionally activated by HIF-1α, act as a miRNA sponge of miR-875-3p, translate a small peptide (66 a.a.), and promote tumor growth and migration in breast cancer cells (Fig. 7D). Here, NDRG1 is linked to breast carcinoma.