Since tumors become more malignant in hypoxia [37, 38], we examined the effects of NDRG1-OT1 in a more common triple-negative breast cancer cell line, MDA-MB-231, which has a shorter doubling time (doubling time: 25 h) than MDA-MB-453 cells (doubling time: 38 h), based on empirical reasons. The gene discussed is NDRG1; the disease is triple-negative breast carcinoma.