Lu et al. demonstrated that the expression of HDAC4 was increased in OA cartilage compared to normal cartilage, and a reduction in HDAC4 levels could significantly suppress the expression levels of Mmp1, Mmp3, Mmp13, and Adamts4/5 in SW1353 chondrosarcoma cells.61 However, it has been shown that the expression of HDAC4 is decreased in OA chondrocytes and increases the expression of Runx2, Mmp13, Ihh, and Col-X. Here, HDAC4 is linked to chondrosarcoma.