ERBB2 and breast carcinoma: Compared with adjuvant chemotherapy, NAC potentially results in less extensive surgery of both breast and axilla, without compromising distant recurrence, breast cancer survival or overall survival (OS).1–3 The degree of response depends largely on sensitivity to therapy and is known to vary in the different breast cancer subtypes, where the highest pathological complete response (pCR) rate is reached within the human epidermal growth factor receptor 2 (HER2)-positive and the triple negative (TN) subtypes.4–7