Thus, our present study is focused on the complex characterization of behavior, metabolic profile, including urine NMR metabolomics employed for the first time, and neuropathological changes in SAMP8 mice in comparison to their SAMR1 controls at several age points that are connected to the progression of AD, especially with respect to inflammation and insulin resistance in the periphery, as well as central insulin resistance, neuroinflammation, tau hyperphosphorylation, and potential decrease in synaptogenesis and neurogenesis. Here, INS is linked to Alzheimer disease.