Altogether, our data indicate that SAMP8 mice, with accelerated age, from their young age, already between the 3rd and 6th months, exhibit early onset pathologies connected to neurodegenerative changes, such as peripheral and central inflammation together with insulin resistance in the periphery, as well as in the hippocampus, where increased tau phosphorylation, as one of the hallmarks of AD, was observed. The gene discussed is INS; the disease is Alzheimer disease.