Missense alteration of SMARCA1 was the most common form and R993Q/*/P mutation in the SLIDE domain was detected in 4 cases of UCEC, 1 case of PRAD and 1 case of STAD (Fig 8B), which may result in frame-shift mutation of the SMARCA1 gene, translation from R (arginine) to Q (glutamine)/P (proline) at the 993 site of SMARCA1 protein and proceeding protein truncation. Here, SMARCA1 is linked to prostate adenocarcinoma.