RPS6KB1 and cancer: Contrary to our expectation of up‐regulation of autophagy in the cancer cells, however, we observed reduction of LC3‐II in the SPL‐overexpressing cell lines, together with enhanced phosphorylated mTOR and p70S6K, which are known to contribute to the regulation of autophagy (Figure 5A), suggesting suppression of autophagy in the SPL‐overexpressing cell lines.