Contrary to reports from previous studies in colon cancer,30, 61, 62 the present study showed that enhanced expression levels of SPL together with the increased levels of glyceroLPLs, were associated with enhanced cell proliferation abilities of the cells, and that the silencing of SPL was associated with reduced cell proliferation, migration, and invasion abilities, with, in particular, reduction of the levels of LPI and LPG. Here, SGPL1 is linked to malignant colon neoplasm.