The patient‐based data in this study further endorsed the possibility that SPL might have important roles in generating glyceroLPLs in HCC, because only the mRNA expression levels (tumour/non‐tumour ratio) of SPL, which is also known to function intracellularly,5 were correlated with the levels of glyceroLPLs (tumour/non‐tumour ratio), such as LPC and LPI, among the sphingolipid‐related factors (Figure 1, Table S3). This evidence concerns the gene SGPL1 and hepatocellular carcinoma.