In our previous studies, however, we observed that in human hepatocellular carcinoma (HCC) and colon cancer tissues, as compared with the adjacent non‐tumour tissues, while the mRNA levels of the SKs were enhanced, the S1P levels remained low or unchanged, suggesting that up‐regulation of SKs does not always uphold the ceramide‐S1P rheostat theory.20, 21. Here, MTOR is linked to hepatocellular carcinoma.