Diphtheria toxin+ (DT+) transgenic mice express the DT receptor (DTR) only on proximal TECs (26) and develop acute kidney injury with proximal tubular injury following DT injection with increased ACR, urinary kidney injury molecule-1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL) (Figure 2B). The gene discussed is HAVCR1; the disease is acute kidney injury.