Diphtheria toxin+ (DT+) transgenic mice express the DT receptor (DTR) only on proximal TECs (26) and develop acute kidney injury with proximal tubular injury following DT injection with increased ACR, urinary kidney injury molecule-1 (KIM-1), and neutrophil gelatinase-associated lipocalin (NGAL) (Figure 2B). This evidence concerns the gene LCN2 and acute kidney injury.