The ability of the treatment to lead to long-term survival, and the fact that these animals did not develop tumors after tumor rechallenge, indicates that the combination of RT plus DDRi not only caused in situ damage to the tumor cells, but also that the cGAS/STING-mediated cytokine release and ICD mechanisms could contribute to the development of an adaptive immune response. Here, STING1 is linked to neoplasm.