We next conducted DNA-IP on plasma samples from healthy human donors (HD), a cohort of patients with HPV-positive head and neck squamous cell carcinoma (HPV+ HNC), a cohort of patients with HPV-negative HNC (HPV– HNC), and a cohort of patients with acute myeloid leukemia (AML) carrying the nucleophosmin 1 (NPM1) type A mutation at the time of diagnosis. Here, NPM1 is linked to head and neck squamous cell carcinoma.