[21, 22] Marzano et al., in a cohort of 527 non-diabetic hypertensive patients, showed that insulin resistance and higher fasting insulin levels correlated with lower Lp(a) levels.[23] In addition, Neele et al. reported a dose-dependent inhibitory effect of high insulin plasma concentration on the hepatic synthesis of Apo(a).[24]. Here, LPA is linked to Insulin resistance.