Currently available treatments include imatinib for KIT alterations in GIST, gefitinib, osimertinib, sotorasib, crizotinib, for alterations in EGFR, KRAS, and ALK fusion in NSCLC, PARP inhibitors, and alpelisib for BRCA1/2 and PIK3CA variants in gynecologic malignancies, and dabrafenib and trametinib for BRAF V600E in melanoma and metastatic papillary thyroid carcinoma.19, 20, 21, 22, 23, 24. This evidence concerns the gene PIK3CA and non-small cell lung carcinoma.