Interferon-α (IFN-α) stimulates the secretion of IP-10 (CXCL10), recruits effector T cells to the tumor microenvironment, and upregulates the expression of MHC-1 molecules on the surface of tumor cells, thereby enhancing the anti-tumor effects of CD8+T cells in the tumor microenvironment [72]. The gene discussed is CD8A; the disease is neoplasm.