To reveal the influence of vaspin on miR‐33a‐5p expression in breast cancer cells, we treated MDA‐MB‐231 cell line with 0, 0.1, 1, 10, 100 ng/mL concentration gradient for 24 h, and then the expression of miR‐33a‐5p was measured by qPCR. The gene discussed is SERPINA12; the disease is breast cancer.