Recent discoveries have highlighted the importance of glycolytic metabolism in the activation of AT macrophages with HFD (Lee et al., 2019), but the metabolic status of monocytes in obesity has not been reported, although some studies have investigated the metabolism of circulating human CD14+CD16- monocytes (homologous to murine tissue invasive Ly6Chigh monocytes) during aging (Lee et al., 2019; Pence and Yarbro, 2019). Here, CD14 is linked to obesity due to melanocortin 4 receptor deficiency.