Recent discoveries have highlighted the importance of glycolytic metabolism in the activation of AT macrophages with HFD (Lee et al., 2019), but the metabolic status of monocytes in obesity has not been reported, although some studies have investigated the metabolism of circulating human CD14+CD16- monocytes (homologous to murine tissue invasive Ly6Chigh monocytes) during aging (Lee et al., 2019; Pence and Yarbro, 2019). The gene discussed is CD14; the disease is obesity disorder.