FSHR and osteoporosis: Finally, we provide genetic evidence, using our Fshr+/- mouse, that haploinsufficiency of the FSHR—which mimics the effect of FSH blockade on osteoporosis (Sun et al., 2006; Ji et al., 2018; Liu et al., 2017)—does not affect lifespan negatively in male or female mice (Figure 4E, Figure 4—source data 1).