In this regard, while negative data with GnRH modulators are mostly confounded by concomitant changes in LH and GnRH (Drake et al., 2010), it is clear that low gonadotropin levels in triptorelin-treated men with prostate cancer are associated with lower fat mass and body weight than men undergoing orchiectomy, where gonadotropins are high (Østergren et al., 2019). Here, GNRH1 is linked to prostate cancer.