However, there is compelling epidemiologic evidence that high serum FSH levels correlate with serum total and LDL cholesterol in post-menopausal women, and importantly, that total cholesterol rises across the perimenopausal transition, essentially tracking closely with bone loss and obesity (Sowers et al., 2007; Sowers et al., 2003a; Song et al., 2016; van Beresteijn et al., 1993). Here, BRD2 is linked to obesity due to melanocortin 4 receptor deficiency.