BRD2 and Mental deterioration: These preclinical data in mice establishing FSH as an actionable target are reinforced by striking estrogen-independent correlations in women between serum FSH, rapid bone loss, visceral obesity, and spikes of cognitive decline during the menopausal transition, at which time serum estrogen is relatively normal and FSH levels are rising (Sowers et al., 2001; Sowers et al., 2007; Sowers et al., 2006b; Randolph et al., 2004; Randolph et al., 2011; Randolph et al., 2003).