TP53 and neoplasm: The p53 gene is mutated in >50% of cancers (Kandoth et al., 2013; Hollstein et al., 1991; Petitjean et al., 2007), and loss of p53 function is considered to be involved in tumor progression, thereby defining TP53 as a tumor suppressor gene (Boutelle and Attardi, 2021; Levine, 2019).