ESR1 and breast cancer: In both cases, broadlyaccepted breast cancer drivers such as BRCA1 and ESR1 are central nodes in the network(Figure 6).The network analysis has revealed severalinfluential DCDs that are not curated CGC genes yet, for example E2F2 and THRA fromsingle-cell (Figure 6 A), and SIN3A from bulk data(Figure 6 B).