Genes in the top 10 of inferred drivers (ranked by Relative CausalImpact) are distributed as follows: one gene has been found to be a confirmedcancer driver (IRF4 ranked in top two), six genes have support from experimental studies(AXL, IGF1R, STC2, MBD3, SATB1, ENO2) and three genes has no literature support yet.IGF1R (our top five) has been found to co-regulate tumourigenes and cancer progressionin breast cancer [39]. This evidence concerns the gene ENO2 and breast cancer.