In addition, tofacitinib suppressed the expression of IL-6, C-X-C motif chemokine ligand 9 (CXCL9), CXCL10, and CXCL11 in TNF-stimulated RA synovial macrophages [13], and expression of IL-6 in oncostatin-stimulated and the expression of C–C motif chemokine ligand 2 (CCL2), CCL5, and CXCL10 in TNF-stimulated RA fibroblast-like synoviocytes [14, 15]. This evidence concerns the gene CCL2 and rheumatoid arthritis.