PTK7 and cancer: Altered expression of PTK7 was initially observed in cancer (Dunn and Tolwinski, 2016; Mossie et al., 1995), but rare missense variants in PTK7 have since been linked to neural tube defects (Lei et al., 2019; Wang et al., 2015) and scoliosis (Hayes et al., 2014) in both humans and animal models, confirming a role in embryonic development.