Accordingly, tumor resistance to immunotherapy was also shown to be acquired through tumor cell-intrinsic mechanisms, including loss-of-function of JNK and PTEN, MYC overexpression, and constitutive WNT signaling (Zaretsky et al., 2016; Sade-Feldman et al., 2017; Peng et al., 2016). This evidence concerns the gene MAPK8 and neoplasm.