In agreement with our previous observations, PLAC8‐ and SPNS1‐KO cell lines displayed substantially reduced infection efficiencies compared with cell lines carrying a control sgRNA, reaching levels similar to those of ACE2‐KO cells (Appendix Fig S1C), although the overall infection differences with respect to control cells were milder in this cellular model despite the efficient knockdown of PLAC8 and SPNS1 (Appendix Fig S1D). This evidence concerns the gene ACE2 and infection.