Strikingly, we do not see alterations in the autophagolysosomal compartment of cells that experience an increased SARS‐CoV‐2 infection efficiency upon overexpression of GFP‐PLAC8, suggesting that, although PLAC8 is molecularly connected to autophagy and lysosomal homeostasis, the autophagolysosomal expansion of PLAC8‐KO cells is not the primary cause of their infection defects. This evidence concerns the gene PLAC8 and infection.