The Morris water maze (MWM) was used to test the learning and memory ability of mice, Nissl staining and immunohistochemistry were used to detect the number of positive cells, and Western blot was used to measure the protein expression of each molecule to investigate whether 8 weeks of the running table exercise intervention would affect the PI3K/Akt/GSK3-β signaling pathway in AD mice and whether it could improve cognitive function by reducing hippocampal neuronal apoptosis. The gene discussed is AKT1; the disease is Alzheimer disease.